The contribution of high-sensitivity troponin T on the diagnosis of coronary artery disease in patients undergoing exercise ECG test Efor testi yapılan hastalarda yüksek duyarlıklı troponin T’nin koroner arter hastalığı tanısına katkısı
Medeniyet Medical Journal, cilt.31, sa.4, ss.274-277, 2016 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 4
- Basım Tarihi: 2016
- Doi Numarası: 10.5222/mmj.2016.274
- Dergi Adı: Medeniyet Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.274-277
- Anahtar Kelimeler: Coronary, Exercise test, hsTnT
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The aim of the study was to investigate the contribution of high-sensitivity troponin T (hsTnT)whose levels increase with exercise test on the diagnosis of coronary artery disease in patients undergoing exercise test. The study included 45 patients (28 male, mean age 54.1±7.6 years), in whom coronary angiography (CAG) was performed. HsTnT levels were measured before and after six hours of exercise test. The change in hsTnT was taken as the difference between hsTnT level before and after exercise. Noncritical coronary stenosis (n=30; 66.7%), and critical coronary stenosis (n=15; 33.3%) were detected in respective number of patients. Among 15 patients who had critical coronary stenosis, 11 (24.4%) had positive hsTnT after exercise. Blood urea nitrogen (BUN) (p=0.005), creatinine (Cr) (p=0.023), hsTnT values (p<0.001) before, and, after exercise tests (p=0.001) in critical CAD group were higher when compared with the non-critical CAD group. HsTnT levels before (OR: 4.863, 95%CI: 2.342-7.384, p<0.001), and after exercise (OR: 6.859, 95%CI: 1.554-12.165, p=0.012), ∆ hsTnT (OR: 6.768, 95% CI: 1.409-12.127, p=0.015) and BUN (OR: 1.083, 95%CI: 0.109-2.059, p=0.03) were detected as independent predictors for critical CAD in multiple logistic regression analysis. The specificity of exercise test combined with hsTnT was 93.3%, while the sensitivity of exercise test combined with hsTnT was 73.3%. Elevated hsTnT after exercise test is a significant independent factor, and has higher sensitivity and specificity than exercise test. We may use hsTnT together with the exercise test and myocardial perfusion scintigraphy.