Predictive factors of gallstone formation after sleeve gastrectomy: a multivariate analysis of risk factors
Surgery Today, cilt.50, sa.9, ss.1002-1007, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50 Sayı: 9
- Basım Tarihi: 2020
- Doi Numarası: 10.1007/s00595-020-01971-2
- Dergi Adı: Surgery Today
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.1002-1007
- Anahtar Kelimeler: Bariatric surgery, Cholelithiasis, Comorbidity, Gallstones, Sleeve gastrectomy
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: Obesity and bariatric surgery are both risk factors for cholelithiasis (CL). However, most previous studies have focused on Roux-en-Y gastric bypass, and limited published data are available for sleeve gastrectomy (SG). Methods: Patients were evaluated in two groups depending on the presence of gallstones (Group I, present; Group II, absent). Demographic characteristics, comorbid diseases, pre-operative blood values, and early and late weight loss rates were compared between the groups. Results: The study included 111 patients with a mean age of 38.9. The mean follow-up period was 20.6 (12–39) months. During follow-up, gallstone formation was observed in 36.9% (n = 41) of patients. Thirteen patients (31.8%) had symptomatic cholelithiasis that was resolved with laparoscopic cholecystectomy. The mean interval between sleeve gastrectomy and the detection of cholelithiasis was 210 days and the mean time of post-operative cholecystectomy was 540 days. A multivariate analysis showed that only dyslipidemia was independently and significantly associated with gallstone formation. There was no significant difference in the weight loss rate between the groups. Conclusions: Although CL development was found to be associated with rapid weight loss in several published studies in post-SG patients, the present study showed no significant difference between the groups in terms of early or late weight loss. Pre-operative dyslipidemia may be associated with an increased risk of developing CL.