Myostatin as a marker for doxorubicin induced cardiac damage
Annals of Clinical and Laboratory Science, cilt.46, sa.1, ss.26-31, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 1
- Basım Tarihi: 2016
- Dergi Adı: Annals of Clinical and Laboratory Science
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.26-31
- Anahtar Kelimeler: Myostatin, cardiac failure, doxorubicin, rat, toxicity
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose. Doxorubicin (DXR) is an effective chemotherapeutic agent but causes severe cardiac failure over known doses. Thus, early detection and prevention of cardiac damage is important. Various markers have been tested for early detection of cardiac damage. Myostatin is a protein produced in skeletal muscle cells inhibits muscle differentiation and growth during myogenesis. Methods. We evaluated the role of myostatin as a marker for showing DXR induced cardiac damage and compared with well known cardiac markers like NT-proBNP, hs-TnT and CK in a rat model of chronic DXR cardiotoxicity. Results. Myostatin, NT-proBNP, and hs-TnT but not CK rose significantly during DXR treatment. Conclusion. Myostatin can be used as an early marker of DXR induced cardiotoxicity.