Impairment of Peripheral Nerve Healing After Nerve Repair in Rats Chronically Exposed To Alcohol
Archives of Medical Research, cilt.40, sa.5, ss.325-330, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 40 Sayı: 5
- Basım Tarihi: 2009
- Doi Numarası: 10.1016/j.arcmed.2009.05.006
- Dergi Adı: Archives of Medical Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.325-330
- Anahtar Kelimeler: Peripheral nerve, Alcoholism, Ethanol
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Background and Aims: The aim of this study was to determine the effect of chronic alcoholism on the healing of repaired peripheral nerve and muscle. Methods: Group 1 rats (n = 9) were fed with an alcohol-free modified liquid diet (MLD) throughout the experiment and received no nerve transection or repair. Group 2 rats (n = 9) were fed the same isocaloric MLD and underwent nerve transection and repair. Group 3 (n = 7) consisted of alcoholic rats without nerve transection and repair and Group 4 (n = 8) consisted of alcoholic rats with nerve transection and repair. To assess the effects of chronic alcoholism on nerve healing, surgical procedures were applied to rats in Groups 2 and 4. After 2 months, posterior tibial nerve and gastrocnemius muscle samples were taken for histological analysis. Results: Group 2 rats displayed a group of atrophic fibers, whereas Group 3 rats showed myophagocytosis and endomysial mononuclear infiltration and type 2 fiber atrophy. Group 4 rats displayed a large section of atrophic fibres. Axonal loss, prominent regenerative clusters and endoneural fibrosis occurred in Group 2 rats. Axonal and myelin degeneration, myelin remnants and thinly myelinated axons were exhibited in Group 3 rats, whereas severe axonal loss, myelin degeneration, regenerative clusters and endoneural fibrosis were discovered in Group 4. There was a significant difference in the number of myelinated axons among the various groups of rats. Conclusions: Our findings show that chronic alcoholism has a negative influence on peripheral nerve regeneration associated with a significant decrease in axon number and increased axonal degeneration. © 2009 IMSS.