Plasma MDA levels, GSH-Px activities and nitrite/nitrate levels in patients with familial Mediterranean fever Ailesel Akdeniz Ateşi Hastalarında Plazma MDA Düzeyi, GSH-Px Aktivitesi ve Nitrit/Nitrat Düzeyi
Journal of Clinical and Analytical Medicine, cilt.1, sa.1, ss.1-5, 2010 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 1 Sayı: 1
- Basım Tarihi: 2010
- Doi Numarası: 10.4328/jcam.10.1.11
- Dergi Adı: Journal of Clinical and Analytical Medicine
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.1-5
- Anahtar Kelimeler: Familial Mediterranean Fever, Oxidative Stress, Nitric Oxide
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Aim One of the genetic diseases known to adversely affect endothelial function is familial Mediterranean fever (FMF). The purpose of this study is to investigate the status of oxidative stress and nitric oxide (NO) related parameters in patients with FMF. Material and Methods 41 subjects with FMF (38 male - 3 female) and 32 healthy control subjects (29 male - 3 female) were selected from Turkish population. Glutathione peroxidase (GSH-Px), malond¡aldehyde (MDA), and nitrit/nitrat (NO2-/NO3_) levels were investigated in all subjects. Results MDA and NO2-/NO3- levels of patients in the acute phase were significantly higher than those of control (p< 0.001). No significant difference was found in GSH-Px activities between in the acute phase patients and the control subjects. MDA and NO2-/NO3- levels of patients in the attack-free period were also significantly higher than those of control (p< 0.001). No significant difference was found between the patients in the attack-free period and the control according to GSH-Px activities. Conclusions Our findings point out that oxidative status and NO metabolism is affected in FMF patients. High MDA and NO2-/NO3- levels in the attack-free phase of patients may be due to the certain period of time needed for the relief of lipid peroxidation and the reversal of NO pathway activation.