Efficacy of the second micro–testicular sperm extraction after failed first micro–testicular sperm extraction in men with nonobstructive azoospermia
Fertility and Sterility, cilt.115, sa.4, ss.915-921, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 115 Sayı: 4
- Basım Tarihi: 2021
- Doi Numarası: 10.1016/j.fertnstert.2020.10.005
- Dergi Adı: Fertility and Sterility
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, Gender Studies Database, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.915-921
- Anahtar Kelimeler: Nonobstructive azoospermia, male infertility, micro-TESE
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To evaluate the efficacy of the second micro–testicular sperm extraction (TESE)in men with nonobstructive azoospermia in whom the first micro-TESE failed. Design: Retrospective. Setting: Private clinic. Patient(s): One hundred twenty-five men with nonobstructive azoospermia with failed previous micro-TESE. The patients were divided into 2 groups according to their surgical sperm retrieval status during the second micro-TESE. If sperm could not be found, these patients were classified as Group 1, and, if sperm was found, the patients were classified as Group 2. The 2 groups were compared for clinical parameters and pathologic findings. Intervention(s): Micro-TESE. Main Outcome Measure(s): Surgical sperm retrieval status. Result(s): Sperm was recovered successfully in 23 of 125 (18.4%) men with the second micro-TESE. Testicular volume was significantly lower in Group 2 (8.2 ± 5.4 mL) than Group 1 (11.3 ± 5.3 mL). Seven of 14 (50%) patients with Klinefelter's Syndrome had sperm recovery with repeat micro-TESE. The sperm retrieval rate was significantly higher in the Leydig cell hyperplasia and tubular sclerosis groups than in the Sertoli cell only and maturation arrest groups (54.5%, 10.1%, and 18.6%, respectively). Conclusion(s): On the basis of our results, 18.4% of men with failed first micro-TESE had a probability of sperm retrieval with the second micro-TESE. Patients with successful sperm recovery had smaller testicular volumes than those with a failed second attempt. Severe testicular atrophy was not a contraindication for the second micro-TESE in such patients.