Aripiprazole augmentation of clomipramine therapy in treatment-resistant obsessive-compulsive disorder: Case series
Dusunen Adam - The Journal of Psychiatry and Neurological Sciences, cilt.29, sa.2, ss.167-172, 2016 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 2
- Basım Tarihi: 2016
- Doi Numarası: 10.5350/dajpn2016290209
- Dergi Adı: Dusunen Adam - The Journal of Psychiatry and Neurological Sciences
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.167-172
- Anahtar Kelimeler: Aripiprazole, clomipramine, obsessive-compulsive disorder, treatment resistance
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Obsessive-compulsive disorder (OCD) is a chronic disorder characterized by recurrent intrusive thoughts and repetitive rituals, causing significant distress and functional loss. Studies show evidence about serotonergic and dopaminergic mechanisms in neuropathogenesis of OCD. Selective serotonin re-uptake inhibitors (SSRI) are considered as first-line treatment in OCDs, but treatment resistance may occur in 40-60% of cases treated with SSRIs. Augmentation of antidepressants with atypical antipsychotics is an important treatment option in treatment-resistant patients with OCD. In this article, we aimed to present five OCD cases with treatment-resistance in which we obtained good outcomes, with addition of aripiprazole 10-30mg per day to clomipramine therapy.