Long-term results of patients treated with bronchoscopic lung volume reduction
Gulhane Medical Journal, cilt.63, sa.3, ss.193-199, 2021 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 63 Sayı: 3
- Basım Tarihi: 2021
- Doi Numarası: 10.4274/gulhane.galenos.2021.1536
- Dergi Adı: Gulhane Medical Journal
- Derginin Tarandığı İndeksler: Scopus, Academic Search Premier, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.193-199
- Anahtar Kelimeler: bronchoscopic lung volume reduction, Emphysema, endobronchial valve, lung volume reduction coil, respiratory function tests
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aims: Surgical and bronchoscopic treatments are tried to reduce hyperinflation together with medical treatments in patients with chronic obstructive pulmonary disease (COPD) and emphysema. Therefore, bronchoscopic lung volume reduction (BLVR) procedures can improve the success of treatment and quality of life of patients. Methods: We investigated the efficacy and safety of BLVR treatment retrospectively. Demographic characteristics, modified Medical Research Council (mMRC) and COPD assessment test (CAT) questionnaires, 6-minute walking distance (6-MWD) and all pulmonary function tests of the patients, who were treated with BLVR, were examined. The values before the procedure and the values at the third and sixth months after the procedure were analyzed statistically. Results: Twenty-five patients were examined (one was female). Six patients (59±10.4 years, forced expiratory volume in 1 s (FEV1) 21.7±5.7% pred) were bronchoscopically treated with coils, with a median of 9.33 (range 8-11) coils per procedure. Nineteen patients (65.8±6 years, FEV1 26.9±9% pred) were treated with valves, with a median 3.52 (range 3-4) valves per patient. At 3 and 6 months, respectively, ΔCAT was −4.8±6 and −7.5±7.2 points, Δ6-MWD was +103.4±139 m and +160.8±149 m [endobronchial valve (EBV)], ΔFEV1 was +0.15±0.3 L and +0.21±0.3 L, ΔFVC was +0.44±0.7 L and +0.5±0.7 L, (all p<0.05), and ΔRV (residual volume) was −0.52±1.1 L and 0.32±1.5 L (p>0.05). Conclusions: In our study, BLVR (EBV and coil) treatments were used in patients with severe to very severe emphysema in COPD, in appropriate indications and in selected cases, and statistically significant well-being was observed in spirometric parameters in the first six months after the procedure.