High - dose methylprednisolone - induced dramatic maturation of granulocytes in idiopathic chronic neutropenia
Turkish Journal of Pediatrics, cilt.39, sa.2, ss.259-263, 1997 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39 Sayı: 2
- Basım Tarihi: 1997
- Dergi Adı: Turkish Journal of Pediatrics
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.259-263
- Anahtar Kelimeler: idiopathic chronic neutropenia, high-dose methylprednisolone
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Idiopathic chronic neutropenia is characterized by a variable pattern of age at the onset of neutropenia, neutrophil counts, maturational arrest at the promyelocyte/myelocyte stage in the bone marrow, and recurrent pyogenic infections without any underlying disease or drug administration.There have been reports of lack of response to conventional-dose steroid therapy, but in recent studies it has been shown that high-dose corticosteroids are effective in several neutropenic states. Here we report an apparent response to high-dose methylprednisolone in a patient with idiopathic chronic neutropenia.