Fetal valproate syndrome and hypothyroidism: Case report Fetal valproat sendromu ve hipotiroidi
Turkiye Klinikleri Pediatri, cilt.20, sa.1, ss.66-69, 2011 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 20 Sayı: 1
- Basım Tarihi: 2011
- Dergi Adı: Turkiye Klinikleri Pediatri
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.66-69
- Anahtar Kelimeler: Hypothyroidism, Valproic acid
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Fetal valproate syndrome results from prenatal exposure to valproic acid and is characterized by typical facial apperance, intrauterin growth retardation, central nervous system abnormalities, cardiac and musculoskeletal anomalies. A case with facial features including epicanthal folds, depressed nasal bridge, low set and retrovert ears, hypertelorism and intrauterine growth retardation, microcephaly, congenital cardiovascular anomalies including atrial septal defect, partial anomalous pulmonary venous return, double superior vena cava and patent ductus arteriosus, agenesis of bilateral radii and absence of first metacarp and phalanges on hand fingers and hypothyroidism is presented. Here, we report a case of hypothyroidism, which might have been occured incidentally, with fetal valproate syndrome resulted from prenatal exposure to high dose valproic acid in organogenesis period in order to draw attention to expanded teratogenic spectrum of valproic acid that has been reported on literature. Copyright © 2011 by Türkiye Klinikleri.