Drug-Functionalized Nanoparticles for Clinical Applications
Emerging Sustainable Nanomaterials for Biomedical Applications, Springer Nature, ss.409-465, 2024
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2024
- Doi Numarası: 10.1007/978-3-031-63961-6_16
- Yayınevi: Springer Nature
- Sayfa Sayıları: ss.409-465
- Anahtar Kelimeler: Clinical trials, Nanoformulation, Nanotheranostics, Nanotoxicity, Targeted therapy
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In this chapter, we have summarized the types of drug-functionalized nanoparticles (NPs) and their clinical applications. Focusing on the integration of nanotechnology in drug delivery systems (DDS), passive, active, and stimuli-responsive targeting strategies were discussed. Their role in optimizing drug efficacy, ensuring precise targeting, appropriate dosing, and minimized side effects, while also reducing the frequency of drug administration were presented. The paper high-lights the intersection of nanoscience and medicine, illustrating how nanotechnology-enhanced DDS can revolutionize patient care, diagnostics, and treatment of diverse pathologies including cancer and drug-resistant infections. The variety of NPs employed in DDS, such as liposomes, micelles, and dendrimers, and their adaptability to different drug delivery routes were introduced. Nano-DDS that are under clinical trials were mentioned to highlight the shifting trends in the field. This comprehensive overview underscores the potential of drug-functionalized NPs to transform thera-peutic modalities and offers insights into future advancements in this interdisciplinary field.