COPD, AGE, LDH, TROPONIN, D-DIMER, AND CRP/ALBUMIN RATIO: A NEW PROGNOSTIC MODEL FOR COVID-19 KOPB, DOB, LDH, TROPONIN, D-DIMER I OMJER CRP/ALBUMIN: NOVI PROGNOSTIČKI MODEL ZA COVID-19
Acta Clinica Croatica, cilt.64, sa.3, ss.484-498, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 64 Sayı: 3
- Basım Tarihi: 2025
- Doi Numarası: 10.20471/acc.2025.64.03.09
- Dergi Adı: Acta Clinica Croatica
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
- Sayfa Sayıları: ss.484-498
- Anahtar Kelimeler: COVID-19, Mortality, Prognosis, Chronic obstructive pulmonary disease, Lactate dehydrogenase
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The aim of this study was to determine the relationship between demographic char-acteristics, initial laboratory data and comorbidities with prognosis in inpatients followed up for corona-virus disease 2019 (COVID-19) and to create a new model for predicting mortality risk. In this multi-center, retrospective cohort study, patient demographic and clinical data were recorded at the first patient admission to the hospital. The primary outcome was to evaluate the relationship of demographic char-acteristics, laboratory parameters and comorbidities with mortality. Parameters found to be associated with mortality in univariate analyses were also evaluated with multivariate analyses and a final model was established. In the final model, the presence of chronic obstructive pulmonary disease (COPD) (OR: 3.177, 95% CI: 1.574-6.413), age (OR: 1.056, 95%CI: 1.034-1.078), lactate dehydrogenase (LDH) (OR: 1.002, 95%CI: 1.001-1.003), troponin (OR: 1.052, 95% CI: 1.007-1.099), D-dimer (OR: 1.012, 95%CI: 1.002-1.021), and C-reactive protein (CRP)/albumin ratio (OR: 1.278, 95%CI: 1.145-1.427) were found to be associated with mortality. The model accurately predicted mortality with a sensitivity of 82.6% and specificity of 77.7%. COPD, age, LDH, troponin, D-dimer, and CRP/albumin ratio were determined as factors associated with mortality. Assessment of these parameters at the time of admission of inpatients, classifying patients as high risk, and adopting early and appropriate treatment approaches may help in the management of patients.