Immediate effects of methylphenidate on vocal acoustic parameters in children with attention deficit hyperactivity disorder
Klinik Psikofarmakoloji Bulteni, cilt.19, sa.4, ss.365-372, 2009 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19 Sayı: 4
- Basım Tarihi: 2009
- Dergi Adı: Klinik Psikofarmakoloji Bulteni
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.365-372
- Anahtar Kelimeler: Methylphenidate, attention deficit hyperactivity disorder, acoustic variables, voice
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: The children with attention deficit hyperactivity disorder are more talkative and aloud than typical children. Children with attention deficit hyperactivity disorder might abuse their voice more often than others and this might be a risk factor for childhood dysphonia, and hyperfunctional vocal behaviors negatively influence their communications. The studies about vocal acoustic variables in children with attention deficit hyperactivity disorder are very limited; moreover possible effects of the stimulants on vocal acoustic variables are unknown. The purpose of the present study was to evaluate possible vocal acoustic changes following methylphenidate administration in children with attention deficit hyperactivity disorder. Method: The study samples included 22 prepubertal boys that diagnosed to have attention deficit hyperactivity disorder according to the Diagnostic and Statistical Manual of Mental Disorders IV criteria, and have been treated with methylphenidate for at least one year. The voice samples were recorded and analyzed using the Multi Dimensional Voice Program (MDVP) advanced software with MXL stereo medium digital microphone both during baseline (drug free) and after methylphenidate administration. The following acoustic parameters were taken into consideration: s/z ratio, fundamental frequency, jitter, pitch perturbation quotient, shimmer, amplitude perturbation quotient, and noise-to-harmony ratio. Results: Baseline fundamental frequency decreased significantly following methylphenidate administration (p<0.001). Absolute jitter increased significantly at methylphenidate administration period compare to that of baseline session (p= 0.039). There were no statistically significant differences in s/z ratio and the rest of acoustic variables between the baseline and the drug period. Discussion: We suggested that methylphenidate change the resonance of speech production by lowering the fundamental frequency. Thus, methylphenidate would maintain regularization of loudness by controlling motor speech centrally.