Association of immunonutrition-based indices (Hemoglobin-Albumin-Lymphocyte-Platelet, prognostic nutritional index, and C-reactive protein–albumin–lymphocyte) with the latency period in preterm prelabor rupture of membranes
Revista da Associacao Medica Brasileira, cilt.72, sa.4, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 72 Sayı: 4
- Basım Tarihi: 2026
- Doi Numarası: 10.1590/1806-9282.20251977
- Dergi Adı: Revista da Associacao Medica Brasileira
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Anahtar Kelimeler: Fetal membranes, Premature rupture, Nutrition assessment, Inflammation, Infant, premature, Pregnancyoutcome
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
SUMMARY OBJECTIVE: The aim of this study was to evaluate the predictive value of immunonutrition-based indices (Hemoglobin, Albumin, Lymphocyte, Platelet score, prognostic nutritional index, and C-reactive protein–albumin–lymphocyte index) for latency duration and neonatal outcomes in preterm prelabor rupture of membranes. METHODS: This retrospective cohort study included 145 singleton pregnancies diagnosed with PPROM between 24 and 34 weeks. Patients were categorized by latency duration (≤48 vs. >48 h), and subgroup analyses used thresholds of 72 h, 96 h, and 7 days. Maternal, laboratory, and neonatal characteristics were compared. Logistic regression adjusted for parity and gestational age evaluated associations between indices and latency. RESULTS: Hemoglobin, Albumin, Lymphocyte, Platelet, prognostic nutritional index, and C-reactive protein–albumin–lymphocyte values showed no significant differences across latency groups (all p>0.05). Only respiratory distress syndrome was more frequent in the short-latency group (p=0.005). CONCLUSION: Immunonutrition indices remained stable across latency durations, highlighting the predominance of localized inflammatory and structural mechanisms in preterm prelabor rupture of membranes pathophysiology.