Influence of sustained virological responseon apri in chronic hepatitis c: Is APRI a marker of only the stage of fibrosis? Kronik Hepatit C'de Sürekli Virolojik Yanıtın APRI Üzerindeki Etkisi: APRI Sadece Fibrozis Evresinin Bir Belirteci mi?

Bahadır Ö., Özer S., Saltürk A. G. D., Şahin H., Kıyak M., Kanatsız E., ...Daha Fazla

Viral Hepatitis Journal, cilt.26, sa.3, ss.119-123, 2021 (ESCI, Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.4274/vhd.galenos.2020.2020.0012
  • Dergi Adı: Viral Hepatitis Journal
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.119-123
  • Anahtar Kelimeler: HCV, APRI, fibrosis, necroinflammation
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Objectives: Aspartate transaminase (AST) to platelet ratio index (APRI) is widely used to predict the stage of liver fibrosis in patients with chronic hepatit C virus (HCV) infection. In this study, we aimed to evaluate changes in APRI scores in patients with chronic HCV infection who received pegylated interferon (PEG IFN) + ribavirin or direct acting antiviral (DAA) ± ribavirin. Materials and Methods: We retrospectively reviewed our data of patients with chronic HCV infection who received PEG IFN + ribavirin or DAA ± ribavirin. Patients were classified into 3 groups according to sustained virological response (SVR) by treatment regimens: a) SVR with PEG IFN + ribavirin (PEG IFN-SVR), b) non SVR with PEG IFN + ribavirin (PEG IFN-non SVR), c) SVR with DAA ± ribavirin (DAA-SVR). Results: The study included 156 patients. APRI scores decreased significantly in PEG IFN-SVR (1.17±1.37 vs 0.38±0.35) and DAA-SVR groups (0.99±0.88 vs 0.31±0.16) (both p=0.001), whereas it did not change in PEG IFN-non SVR group (1.26±1.07 vs 1.33±1.36) (p=0.810) after treatment. In PEG IFN-SVR and DAA-SVR groups, proportions of patients who had APRI scores ≤0.5 and ≤1 increased, while proportions of patients who had APRI scores >1.5 and >2 decreased significantly after treatment (all p<0.05). Conclusion: APRI score is not indicator of only the stage of fibrosis. Hepatic necroinflammation also influences APRI score by increasing AST levels and decreasing platelet levels.