Investigation of biomarker in laryngeal carcinomas
Journal of Clinical Laboratory Analysis, cilt.28, sa.3, ss.186-190, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 3
- Basım Tarihi: 2014
- Doi Numarası: 10.1002/jcla.21664
- Dergi Adı: Journal of Clinical Laboratory Analysis
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.186-190
- Anahtar Kelimeler: biomarker, laryngeal carcinoma, Podoplanin, squamous cell carcinoma, GST-T1
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: The aim of the study is to determine whether there is a role of podoplanin and glutathione S-transferases T1 (GST-T1) expression in laryngeal squamous cell carcinoma. Methods: In this study, 33 patients were enrolled and gene expression analysis was performed by qRT-PCR. The podoplanin and GST-T1 expression patterns were analyzed to determine their correlation with clinicopathologic parameters of laryngeal cancer. Results: Of all included patients, 20 had supraglottic, and 13 had glottic laryngeal cancer. Increased expression of podoplanin was found in seven (35%) supraglottic tumor tissues and seven (53.8%) glottic tumor tissues, but GST-T1 expression was not detected. Conclusion: Podoplanin expression did not show any prediction for tumor differentiation, regional metastasis, thyroid cartilage invasion, lymphatic vessel invasion, or tumor differentiation for laryngeal cancer, and also there were no significant differences in podoplanin expression between glottic and supraglottic regions, but extracapsullar extension is almost statistically significance (P = 0.05). © 2014 Wiley Periodicals, Inc.