The Effect of Serum Uric Acid Level on Stroke Severity Serum Ürik Asit Düzeyinin İnme Şiddetine Etkisi
Medical Journal of Bakirkoy, cilt.21, sa.4, ss.343-349, 2025 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 4
- Basım Tarihi: 2025
- Doi Numarası: 10.4274/bmj.galenos.2025.2024.7-8
- Dergi Adı: Medical Journal of Bakirkoy
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.343-349
- Anahtar Kelimeler: Ischemic stroke, uric acid, NIHSS score, stroke severity
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Stroke remains a leading cause of disability and mortality globally, affecting millions annually. Recognizing and managing stroke risk factors is essential for reducing its prevalence and improving patient outcomes. Among the various risk factors, uric acid (UA) has garnered attention for its potential role in stroke pathophysiology. This study investigates the effect of serum UA level on stroke severity, aiming to enhance understanding and management of stroke. Methods: A retrospective analysis was performed involving 110 patients diagnosed with acute ischemic stroke (Group 1) and 83 individuals in the healthy control group (Group 2) between August 2016 and August 2017. The average serum UA level was measured in two different groups and was analyzed together with other contributors to stroke risk. Stroke severity was evaluated in relation to serum UA levels, utilizing the National Institutes of Health Stroke Scale (NIHSS). Results: In group 1, the average serum UA level was 5.5 mg/dL, while in Group 2, it was 4.8 mg/dL, with a statistically significant difference identified between the groups (p<0.001). A serum UA threshold of 5.6 mg/dL was determined (p<0.001), and exceeding this threshold alone was recognized as a predisposing factor for ischemic stroke, irrespective of other possible risk factors (odds ratio: 3.107; 95% confidence interval: 1.424, 6.781; p=0.004). There was no significant correlation between serum UA levels and NIHSS scores (p=0.527) Conclusion: The findings of this study indicate that while elevated UA levels might contribute to the development of ischemic stroke, their influence on stroke severity remains uncertain. Further research is necessary to determine whether therapeutic lowering of serum UA could improve stroke outcomes.