Precision Medicine Concept and its Role in the Treatment of Immunological Diseases Precision Medicine (Hassas Tıp) Kavramı ve İmmünolojik Hastalıkların Tedavisindeki Yeri

Özer M., Bostancı İ.

Guncel Pediatri, cilt.19, sa.2, ss.259-270, 2021 (ESCI, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.4274/jcp.2021.0032
  • Dergi Adı: Guncel Pediatri
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database
  • Sayfa Sayıları: ss.259-270
  • Anahtar Kelimeler: Precision medicine, immunological diseases, IVIG, PEG-ADA
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

In the conventional medical understanding, the focus has been on diseases, the same treatment methods have been applied to different individuals with the same disease, but the fact that the same disease will not be the same in different people and therefore the treatment cannot be the same has emerged. For this reason, individuals are more prominent than disease, and in this context, precision medicine concept has entered our lives with the developing technological infrastructure. Although the term precision medicine is relatively new, the concept has been a part of healthcare for many years. In the treatment of immunological diseases, sensitive medicine treatment strategies basically include three different treatment approaches. Replacement of “missing molecules”, inhibition of overactive intracellular signaling and cytokine blockade. Along with the treatment approaches which have been most frequently used in immunology clinics for many years such as IVIG, PEG-ADA and IFN-y, precision medicine also includes relatively rarer treatments that have been discovered lately such as pleriksafor, sirolimus and vedolizumab. Defining new molecular pathways with today’s increasing technological infrastructure will undoubtedly bring the days when the concept of precision medicine will be used more effectively in the treatment of many diseases.