IS THIOL/DISULPHIDE HOMEOSTASIS IMPORTANT IN PROSTATE CANCER DIAGNOSIS?

Senel C., ASLAN Y., Imamoglu M. A., Karakoyunlu A. N., Altinova S., Ozcan M. F., ...Daha Fazla

Archivos Espanoles de Urologia, cilt.73, sa.9, ss.819-825, 2020 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 73 Sayı: 9
  • Basım Tarihi: 2020
  • Dergi Adı: Archivos Espanoles de Urologia
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Gender Studies Database, MEDLINE, DIALNET
  • Sayfa Sayıları: ss.819-825
  • Anahtar Kelimeler: Prostate cancer, Diagnosis, Oxidative stress, Dynamic thiol-disulphide homeostasis
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

OBJECTIVES: To assess the relationship between prostate cancer and thiol/disulphide homeostasis as an important indicator of oxidative stress. METHODS: After ethics committee approval (546/2015); 388 patients aged between 46-75 years who underwent transrectal ultrasound guided prostate biopsy in three different centers between July 2015-2016 owing to serum prostate specific antigen (PSA) levels ≥2.5 ng/ml and/or abnormal digital rectal examination were involved in this study. The plasma levels of thiol/disulphide homeostasis parameters were compared in patients with and without prostate cancer. RESULTS: The mean age of the patients was 62.9±7 years. In patients with prostate cancer (n=130, 33.5%) the mean plasma levels of native thiol and total thiol were lower (332.9 vs 362.1 µmol/L and 363 vs 392.6 µmol/L, p=0.001). Plasma disulphide levels were not statistically different between the groups (15 vs 15.3 µmol/L, p=0.936). In prostate cancer group; patients with Gleason score ≥7 had lower plasma native thiol levels than patients with Gleason score<7 (321.3 vs 342.6 µmol/L, p=0.029) while there were no significant differences in total thiol and disulphide levels (352.3 vs 371.9 µmol/L, ptotal Thiol =0.064 and 15.5 vs 14.6 µmol/L, pdisulphide =0.933). CONCLUSIONS: Lower plasma levels of thiol in patients with prostate cancer and high Gleason score is a noteworthy result. We believe that our results should be supported by further studies.