Is Modified Systemic Inflammation Score a Predictor of Malignancy in Indeterminate Thyroid Nodules? Modifiye Sistemik İnflamasyon Skoru İndetermine Tiroid Nodüllerinde Malignitenin Bir Göstergesi midir?

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Duymaz Y. K., Tekin A. M., Önder S., Şahin Ş., Erkmen B., Savran F., ...Daha Fazla

Journal of Ear Nose Throat and Head Neck Surgery, cilt.31, sa.2, ss.109-114, 2023 (Scopus, TRDizin)

Özet

Objective: The aim of this study is to evaluate the preoperative diagnostic value of modified systemic inflammation score (mSIS) in predicting the presence of malignancy in patients with indeterminate thyroid nodules. Material and Methods: It is a retrospective study. Three hundred and sixty eight patients who underwent thyroid lobectomy were screened. Patients were divided into 3 groups according to modified SIS; mSIS 0 for those were albumin (alb) ≥ 4.0 gr/dL and lymphocyte monocyte ratio (LMR) ≥ 3.4, mSIS 1 for those were alb<4.0 gr/dL or LMR<3.4, mSIS 2 for those were alb<4.0 gr/dL and LMR<3.4. According to the results of the postoperative pathology, the patients were divided into two groups as benign and malignant. Results: The malignancy was found in 24 patients in histopathological examination. Ten (41.7%) of these were micropapillary, 8 (33.3%) were papillary, and 6 (25%) were follicular carcinomas. There was no difference between the malignant and benign groups in terms of LMR and albumin values. mSIS 0 had a 65% malignancy rate, mSIS 1 69.2%, and mSIS 2 66.6%. There was no statistically significant difference between the groups. Conclusion: MSIS may not be a predictor of malignancy in indeterminate thyroid nodules. Further studies are needed to understand this issue.