Mitochondrial transplantation and transfer: The promising method for diseases
Turkish Journal of Biology, cilt.47, sa.5, ss.301-312, 2023 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 47 Sayı: 5
- Basım Tarihi: 2023
- Doi Numarası: 10.55730/1300-0152.2665
- Dergi Adı: Turkish Journal of Biology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Veterinary Science Database, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.301-312
- Anahtar Kelimeler: Mitochondria, mitochondrial transplantation, mitochondrial transfer
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Mitochondria are organelles that serve as the powerhouses for cellular bioenergetics in eukaryotic cells. It is responsible for mitochondrial adenosine triphosphate (ATP) generation, cell signaling and activity, calcium balance, cell survival, proliferation, apoptosis, and autophagy. Mitochondrial transplantation is a promising disease therapy that involves the recovery of mitochondrial dysfunction using isolated functioning mitochondria. The objective of the present article is to provide current knowledge on natural mitochondrial transfer processes, in vitro and in vivo applications of mitochondrial transplantation, clinical trials, and challenges associated with mitochondrial transplantation.