Fulminant hepatic failure and hepatic encephalopathy Fulminan karaciǧer yetersizliǧi ve hepatit ensefalopati
SENDROM, cilt.16, sa.7, ss.73-86, 2004 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 7
- Basım Tarihi: 2004
- Dergi Adı: SENDROM
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.73-86
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Fulminant hepatic failure is a syndrome, which is characterized by accelerated impairment of hepatic functions due to massive hepatocyte necrosis in a patient who is not considered to had hepatic dysfunction. Viral hepatitis is the most frequent determined etiology, constituting 60-70% of the cases. Ischemic events and used medications are other common factors. Hepatic encephalopathy accompanied by coagulapathy, metabolic abnormalities and cardiopulmonary insufficiencies simulate fulminant hepatic failure. Cirrhotic encephalopathy and a precipitating factor accompany 90% of all hepatic encephalopathy cases, with 70-80% of predicted survival rates. The incidence of progression of encephalopathy to comatose state usually is limited to 1%. Encephalopathy due to fulminant hepatic failure constitutes about 10% of all cases and progresses to hepatic coma in 90% of the cases. . The reversible nature of this syndrome suggests a metabolic derangement in the underlying pathogenesis of the disease. A decreased clearance of enterically metabolized substances, and alterations in cerebral neurotransmission due to amino acid metabolism defects; are thought to be the main mechanisms contributing to the disease process. In this article, we intended to review the recent and established etiopathogenetic and diagnostic mechanisms, and therapeutic modalities of fulminant hepatic failure and hepatic encephalopathy.