Effects of inappropriate acetylsalicylic acid use on non-fatal bleedings Uygunsuz asetil salisilik asit kullanımının ölümcül olmayan kanamalar üzerine etkisi

ÖZTÜRK M., TURAN O. E.

Haseki Tip Bulteni, cilt.57, sa.4, ss.396-404, 2019 (Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.4274/haseki.galenos.2019.5131
  • Dergi Adı: Haseki Tip Bulteni
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.396-404
  • Anahtar Kelimeler: Acetylsalicylic acid, primary prevention, non-fatal bleeding
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Aim: This study aims to assess of using asetylsalicyclic acid (ASA) on non-fatal major and minor bleeding events in patients with inappropriate, primary and secondary prevention groups. Methods: Nine thousand, six hundred and fifty-one patients were screened within a one-year period. Patients using ASA for primary and secondary prevention were recorded. A total of 736 patients using ASA were divided into three groups as inappropriate, appropriate primary and secondary prevention. Results: One hundred and two (14%) patients were using ASA inappropriately. The duration of ASA use was 82.9±71.3 months. Thirteen (1.8%) major (11 gastrointestinal, one intraocular, one intracranial) and 29 minor (3.9%) bleedings had occurred. Eleven (2.5%) major bleeding events had occurred in secondary prevention group and one (0.5%) in appropriate and one (1%) in inappropriate primary prevention group (p=0.16). Nineteen (4.4%) and 10 (5.1%) minor bleeding events were seen in appropriate and secondary prevention groups, respectively and there was no minor bleeding event occurred in inappropriate primary prevention group (p=0.078). Conclusion: Our study showed that inappropriate ASA use did not increase the risk of non-fatal major and minor bleeding events. It may be reasonable to consider that patients without a history of occlusive vascular disease are less prone to non-fatal bleeding events compared to those with occlusive vascular disease.