Viral load as a predictor of outcome in Crimean-Congo hemorrhagic fever
Clinical Infectious Diseases, cilt.45, sa.7, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 45 Sayı: 7
- Basım Tarihi: 2007
- Doi Numarası: 10.1086/521244
- Dergi Adı: Clinical Infectious Diseases
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Crimean-Congo hemorrhagic fever (CCHF) is a potentially fatal disease affecting multiple organ systems. To determine the association between viral load and severity of CCHF infection, quantitative measurement of CCHF virus was performed using 1-step reverse-transcriptase polymerase chain reaction for 36 patients with CCHF infection. Viral loads ranged from 1.1 × 103 copies/mL to ≥ 9.9 × 109 copies/mL. Nine (25%) of 36 patients died. In 8 of the 9 patients with fatal outcomes, viral loads were detected that were ≥ 1 × 109 copies/mL, whereas in 25 of the 26 patients with nonfatal outcomes, viral loads were detected that were <1 × 109 copies/mL (P < .001). A viral load ≥1 × 109 RNA copies/mL can be considered to predict a fatal outcome with a positive predictive value of 80%, with 88.9% sensitivity and 92.6% specificity. We suggest that viral load is a measure of the severity of CCHF. © 2007 by the Infectious Diseases Society of America. All rights reserved.