Association of neutrophil-to-lymphocyte ratio with myocardial infarct size and clinical outcomes in patients with anterior STEMI after successful primary percutaneous coronary intervention
Experimental and Clinical Cardiology, cilt.20, sa.1, ss.2130-2150, 2014 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 20 Sayı: 1
- Basım Tarihi: 2014
- Dergi Adı: Experimental and Clinical Cardiology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.2130-2150
- Anahtar Kelimeler: Clinical outcomes, Myocardial infarct size, Neutrophil-to-Lymphocyte ratio, Primary percutaneous coronary intervention, STEMI
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The neutrophil-lymphocyte ratio (NLR) is an inflammatory marker of adverse cardiac events in ST segment elevation myocardial infarction (STEMI). Whether admission NLRs before a percutaneous coronary intervention (PCI) directly reflect a larger myocardial infarct size and left ventricular impairment is not enough known. The consecutively 72 patients, who had first anterior STEMI, were successfully reperfused with PCI; and were then evaluated by gated single photon emission computed tomography imaging at rest. The summed rest scores, number of infarcted segments and infarct size ratio were significantly increased in the higher NLR group (15.6±5.6 vs.11.9±5.7, p=0.006; 6.4±1.4 vs.5.36±1.9, p=0.016; 33.9±16.0 vs.23.4±10.2; p=0.001,respectively). The higher NLR group has lower left ventricular ejection fraction (46.0±7.9 vs.40.8±10.9; p=0.024). The higher NLRs were associated with the adverse clinical outcomes [10 (28%) vs.2 (5%);p=0.012]. The NLR can be measured upon admission of STEMI patients to identify patients with increased risk of developing a larger myocardial infarction and increased heart failure. Therefore, the NLR is useful biomarker for determining which patients may show poor prognosis after successful revascularization. We believe that this information will be useful in the risk evaluation of STEMI patients treated with primary PCI.