Analysis of the Effect of Glucagon Secretion on Glucose Concentration During Insulin Infusion İnsülin İnfüzyonunda Glukagon Sekresyonun Glikoz Konsantrasyonuna Etkisinin Analizi

Aydin P. H., KARAASLAN F.

2024 Medical Technologies Congress, TIPTEKNO 2024, Muğla, Türkiye, 10 - 12 Ekim 2024, (Tam Metin Bildiri)

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Doi Numarası: 10.1109/tiptekno63488.2024.10755478
  • Basıldığı Şehir: Muğla
  • Basıldığı Ülke: Türkiye
  • Anahtar Kelimeler: glucose concentration, glucagon secretion, insulin infusion, mathematical model
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Insulin and glucagon hormones play a critical role in the regulation of glucose concentration. While insulin facilitates the uptake and storage of glucose in cells, glucagon supports the release of glucose into the bloodstream by increasing glucose production in the liver. In this study, glucagon mechanisms were integrated into the glucose and insulin dynamics of the mathematical model developed by Stolwijk and Hardy. Simulations were conducted using this model to analyze the effects of glucagon on blood glucose concentration during and after insulin infusion. As a result, according to the model, glucagon has no effect on blood glucose concentration during insulin infusion.