Increased gamma-glutamyl transferase level is associated with absence of coronary collateral vessels in patients with acute coronary syndrome: An observational study Akut koroner sendromlu hastalarda artmış gamma-glutamyl transferase seviyesi koroner kollateral damar yokluǧu ile ilişkilidir: Gözlemsel bir çalışma
Anadolu Kardiyoloji Dergisi, cilt.12, sa.8, ss.652-658, 2012 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 8
- Basım Tarihi: 2012
- Doi Numarası: 10.5152/akd.2012.217
- Dergi Adı: Anadolu Kardiyoloji Dergisi
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.652-658
- Anahtar Kelimeler: Gamma-glutamyl transferase, coronary collateral vessel, acute coronary syndrome, regression analysis, sensitivity, specificity
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Elevated serum gamma-glutamyl transferase (GGT) level has been proposed as a risk factor for coronary artery disease and is associated with poor clinical outcome in acute coronary syndrome (ACS). We aimed to evaluate the relationship between GGT level and pres-ence of coronary collateral vessels (CCV) patients with ACS. Methods: We evaluated 178 patients with ACS in this cross-sectional-observational study. Traditional laboratory and clinical parameters and serum GGT levels were measured. All patients underwent coronary angiography on the first day after admission and patients who had >80% stenosis of coronary artery were included in the study. The CCVs graded according to the Rentrop scoring system and Rentrop 0, 1, 2 and 3 were determined in respectively 76 (42.7%), 32 (18.0%), 33 (18.5%), and 37 (20.8%) patients. Rentrop grade 0 was accepted as no CCV development (Group 1), Rentrop grades 1-2-3 were accepted as presence of CCV development (Group 2). Statistical analysis was performed using independent-samples t, Mann-Whitney U and Chi-squared tests, logistic regression and receiver operator curve analyses. Results: Mean age was 62±10 years and 134 (75.3%) of patients were male. Group 1 consisted of 76 (42.7%) patients and Group 2 consisted of 102 (57.3%) patients. The median and minimum-maximum values of serum GGT were 33.5 (8-128) U/L for Group 1 and 23 (2-83) U/L for Group 2. Absence of CCV was significantly associated with high levels of GGT (p<0.001), alanine-aminotransferase (p=0.001), glucose (p=0.011) and low levels of total protein (p=0.020). At multivariate analysis, high levels of GGT were independent predictors of absence of CCV (OR=0.953, 95%CI 0.912-0.996, p=0.031). Conclusion: High levels of GGT on admission were associated with absence of CCV in patients with ACS. © Telif Hakki(dotless); 2012 AVES Yay i(dotless);nc i(dotless);l i(dotless);k Ltd.