Assessment of autoimmune thyroiditis in Turkish children with celiac disease
Gulhane Medical Journal, cilt.67, sa.3, ss.145-150, 2025 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 67 Sayı: 3
- Basım Tarihi: 2025
- Doi Numarası: 10.4274/gulhane.galenos.2025.48264
- Dergi Adı: Gulhane Medical Journal
- Derginin Tarandığı İndeksler: Scopus, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.145-150
- Anahtar Kelimeler: Autoimmune, celiac disease, children, thyroiditis, ultrasonography
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aims: It has been reported that there is a link between celiac disease and other autoimmune diseases in children. We aimed to compare the presence of autoimmune thyroid disease in children with celiac disease and the ultrasonographic evaluations of these patients with healthy controls. Methods: This cross-sectional, case-control study enrolled pediatric patients diagnosed with celiac disease and healthy children as controls. All patients and controls were tested for celiac antibodies (anti-tissue transglutaminase immunoglobulin A), thyroid function tests (thyroid-stimulating hormone, free thyroxine, free triiodothyronine, thyroid peroxidase antibody, and anti-thyroglobulin antibody), and thyroid ultrasonography. The primary endpoint was the difference in the frequency of autoimmune thyroiditis between patients and controls. Results: The study included 50 children with celiac disease [mean±standard deviation (SD) age: 10.98±3.84, 59% girls] and 50 healthy controls (mean±SD age: 11.36±4.17 years, 65% girls). Five patients (10%) with celiac disease and none of the controls were diagnosed with autoimmune thyroiditis at the time of enrolment (p=0.022). No relationship was identified between the severity of small bowel pathology and autoimmune thyroiditis in patients with celiac disease. Additionally, no significant differences were observed in the ultrasonographic evaluation between celiac patients and controls. Conclusions: In this low-sample study, patients with celiac disease were more likely to have autoimmune thyroiditis than the controls. However, the severity of small bowel damage in celiac disease may not be associated with autoimmune thyroiditis.