A randomized controlled study of the efficacy of misoprostol and hyaluronic acid in preventing adhesion formation after gynecological surgery: A rat uterine horn model

Kaya C., Sever N., Cengiz H., YILDIZ Ş., Ekin M., YAŞAR L.

European Journal of Obstetrics and Gynecology and Reproductive Biology, cilt.176, sa.1, ss.44-49, 2014 (SCI-Expanded, Scopus)

Özet

Objective To investigate the effect of misoprostol in the reduction of adhesion formation after gynecological surgery. Study design A double blind, randomized controlled experimental study was designed. Twenty-one female Wistar Hannover rats were divided into three groups as control, misoprostol and Hyalobarrier® groups. A uterine horn adhesion model was created. After anesthesia induction, 1.5-2 cm injuries were made to the each uterine horn by cautery. The control group received no special medications except for the standard surgical procedure. The misoprostol group received 10 μcg/kg misoprostol in addition to the standard surgical procedure, and the Hyalobarrier® group received 1 cm 3 ready-for-use Hyalobarrier® gel intraperitoneally in addition to the standard surgical procedure. After 14 days from the first surgical procedure, adhesion scores were evaluated. Results The extent (p < 0.001), severity (p < 0.001), degree (p < 0.001) and total adhesion score (p < 0.001) values of the control group were statistically higher than the values of misoprostol and Hyalobarrier® groups. The inflammation score value of misoprostol group was statistically lower than control and Hyalobarrier® groups (p < 0.001). Conclusion In this study, we have found a new therapeutic potential of misoprostol that may be useful in preventing pelvic adhesion and reducing inflammation scores. © 2014 Elsevier Ireland Ltd.