Prognostic value of the CALLY index in patients undergoing transcatheter aortic valve implantation

ASLAN S., Demir A. R., Demirci G., Aydın E., Aydın M. Y., UYGUR B., ...Daha Fazla

Biomarkers in Medicine, cilt.20, sa.8-9, ss.519-530, 2026 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 8-9
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1080/17520363.2026.2692041
  • Dergi Adı: Biomarkers in Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE, MEDLINE, Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Health Research Premium Collection (ProQuest), Pharma Collection (ProQuest)
  • Sayfa Sayıları: ss.519-530
  • Anahtar Kelimeler: All-cause mortality, C-reactive protein-albumin-lymphocyte index, inflammation-nutrition-immune biomarkers, prognosis, transcatheter aortic valve implantation
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Aims: The C-reactive protein–albumin–lymphocyte (CALLY) index is a composite biomarker reflecting inflammation, nutritional status, and immune response. This study evaluated the association of the CALLY index with all-cause mortality in patients undergoing transcatheter aortic valve implantation (TAVI). Methods: In this retrospective study, 733 consecutive TAVI patients were classified as Low-CALLY (≤0.95) or High-CALLY (>0.95) using an ROC-derived cutoff. The primary endpoint was all-cause mortality during follow-up. Predictors of mortality were assessed using Cox proportional hazards regression, while discriminative performance and survival were evaluated by ROC and Kaplan–Meier analyses. Results: Mortality was higher in the Low-CALLY group than in the High-CALLY group (57.1% vs. 19.3%; p < 0.001). The CALLY index showed moderate discrimination for mortality (AUC 0.719; 95% CI 0.681–0.757; p < 0.001). In multivariable Cox regression, Low CALLY remained independently associated with mortality in the clinical model (HR 3.31; 95% CI 2.49–4.39), STS-PROM-adjusted model (HR 3.16; 95% CI 2.37–4.22), and EuroSCORE II-adjusted model (HR 3.72; 95% CI 2.84–4.88) (all p < 0.001). Kaplan–Meier analysis showed lower survival in the Low-CALLY group (log-rank p < 0.001). Conclusion: The CALLY index was independently associated with mortality after TAVI and may complement established risk scores in pre-procedural risk stratification.