Use of benzodiazepines before 18 F-FDG-PET/CT dual-phase imaging does not decrease the efficacy of the study
Indian Journal of Nuclear Medicine, cilt.27, sa.1, ss.24-29, 2012 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 1
- Basım Tarihi: 2012
- Doi Numarası: 10.4103/0972-3919.108838
- Dergi Adı: Indian Journal of Nuclear Medicine
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.24-29
- Anahtar Kelimeler: Alprazolam, benzodiazepines, dual-phase imaging, F-18 FDG PET/CT
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: We aimed to investigate whether administration of benzodiazepines decreases the efficacy of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography PET/CT) ( 18 F-FDG-PET/CT) dual-phase imaging. Materials and Methods: Eighteen patients with malignant tumors who were administered 0.5 mg alprazolam before undergoing 18 F-FDG-PET/CT scan (group A) and 21 patients with malignant tumors who were not administered alprazolam before 18 F-FDG-PET/CT scan (group B) were included in this study. Forty lesions from the 18 patients in group A and 66 lesions from the 21 patients in group B were evaluated. Initial early whole-body imaging commenced 60 ± 5 minutes after injection of 18 F-FDG and delayed scan was obtained 120 ± 10 minutes after the injection. Maximum standardized uptake values (SUVs) were obtained by drawing three-dimensional regions of interest (ROIs) around each lesion on the early study and the corresponding lesion on the delayed study. Results: The average SUV max in lesions in group A (mean ± S.D.) was 10.2 ± 6.4 on early examination (SUV max E) and 12.6 ± 7.6 on delayed examination (SUV max D). There was a significant difference between these two time points ( P < 0.05). Similarly, for the lesions in group B, the average uptake values were 9.3 ± 5.2 (SUV max E) and 11.2 ± 6.5 (SUV max D). The increase in these values was significant as it was in group A ( P < 0.05). Differences between groups A and B for the variables SUV max E, SUV max D were not significant statistically ( P > 0.05). Conclusion: Benzodiazepines do not adversely affect the efficacy of the dual-phase FDG-PET imaging technique.