Amplification of the c-myc oncogene in non-small cell lung cancer
Tumori, cilt.85, sa.6, ss.508-511, 1999 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 85 Sayı: 6
- Basım Tarihi: 1999
- Doi Numarası: 10.1177/030089169908500616
- Dergi Adı: Tumori
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.508-511
- Anahtar Kelimeler: C-myc oncogene, Gene amplification, Non-small cell lung carcinoma
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Fresh non-small cell lung carcinoma surgical specimens were taken from 17 patients and 3 controls and screened for genetic abnormalities of the c- myc oncogene. Southern blot hybridization analysis demonstrated two- to fivefold amplification of the c-myc gene in 10 cases, i.e., 7 of 13 epidermoid lung carcinomas, 2 of 3 adenocarcinomas and 1 of 1 osteogenic sarcoma metastatic to the lung. Two- to fivefold amplification was observed in tissues from stage III and IV epidermoid carcinomas and adenocarcinomas of the lung. A correlation between cancer stage and c-myc gene amplification was found.