Treatment of lateral epicondylitis using betahistine dihydrochloride
Journal of Musculoskeletal Pain, cilt.19, sa.4, ss.201-206, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19 Sayı: 4
- Basım Tarihi: 2011
- Doi Numarası: 10.3109/10582452.2011.609643
- Dergi Adı: Journal of Musculoskeletal Pain
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.201-206
- Anahtar Kelimeler: Lateral epicondylitis, elbow pain, tennis elbow, betahistine dihydrochloride
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives Lateral epicondylitis is a commonly encountered problem. Disruption of microcirculation is hypothesized in the pathophysiology of lateral epicondylitis. Betahistine dihydrochloride [BHD] is used in our study for its microcirculation increasing activity. Methods After hospital ethics committee approval and getting written informed consent from patients, adult patients with lateral epicondylitis were recruited in this randomized study. One group received 48mg/day BHD for 10 days. The control group received 750mg/day naproxen sodium [NS] for 10 days. Visual Analog Scale [VAS] and Verhaar criteria were evaluated before and after treatment. Results Fifty-five patients [41 females, 14 males], mean age 40 years [2163 years] participated. The VAS before treatment was not significantly different between groups. In the NS group, mean VAS after the 10th day, third month, and sixth month were found to be significantly higher than that of the BHD group [P=0.0001]. Verhaar criteria after the 10th day of treatment in the BHD group were significantly improved when compared with the NS group [P=0.008]. Evaluation of clinical findings showed no difference between groups before treatment, but 10th day, third, and sixth month symptoms were found to be lesser in the BHD group when compared with the NS group [P=0.001; P=0.001; P=0.001, respectively]. Conclusions The microcirculation increasing agent BHD restored the signs and symptoms of lateral epicondylitis. In conclusion BHD, which is a histamine agonist, is a favorable choice in the treatment of lateral epicondylitis. © 2011 Informa Healthcare USA, Inc.