Hypoxia-inducible factor-1α and ischemia-modified albumin levels in intensive care COVID-19 Patients
Hormone Molecular Biology and Clinical Investigation, cilt.43, sa.4, ss.415-420, 2022 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 43 Sayı: 4
- Basım Tarihi: 2022
- Doi Numarası: 10.1515/hmbci-2022-0024
- Dergi Adı: Hormone Molecular Biology and Clinical Investigation
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, Chemical Abstracts Core, EMBASE, MEDLINE
- Sayfa Sayıları: ss.415-420
- Anahtar Kelimeler: COVID-19, hypoxia-inducible factor, ischemiamodified albumin, receiver operating characteristic
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: In this study, it was aimed to evaluate the hypoxia-inducible factor-1α (HIF-1α) and ischemia-modified albumin (IMA) levels of patients diagnosed with COVID-19 in the intensive care unit (ICU) and healthy controls. To our knowledge, this is the first study investigate HIF-1α and IMA levels in COVID-19 patients in ICUs and comparing them with a healthy control group. For this reason, our study is original and will contribute to the literature. Methods: A total of 70 intensive care patients diagnosed with COVID-19, and 72 healthy controls were included in the study. Results: When we compared the patient and healthy control group; there were no statistically significant differences between the groups in terms of age and gender (p>0.05). No exitus was observed in the patient group. We found weak correlation between HIF-1α and IMA (r: 0.320). However, there were statistically significant differences in HIF-1α and IMA levels in the patient group. The receiver operating characteristic (ROC) curve demonstrated an area under curve (AUC) value of 0.651 for HIF-1α and 0.937 for IMA. Conclusions: The HIF-1α and IMA levels were significantly higher among COVID-19 patients in ICU compared with healthy controls. HIF-1α and IMA levels can be used as reliable markers for the prognosis of COVID-19.