Beneficial Effects of Taurine Treatment on Experimental Myositis-induced Rats TAURİN TEDAVİSİNİN DENEYSEL MİYOZİT OLUŞTURULMUŞ RATLAR ÜZERİNDEKİ YARARLI ETKİLERİ

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Torlak Koca N., Özüdoğru Çelik T.

Journal of Kirikkale University Faculty of Medicine, cilt.25, sa.3, ss.531-540, 2023 (Scopus, TRDizin)

Özet

Objective: Taurine is an amino acid abundantly present in skeletal muscle, and it possesses cytoprotective properties, including the preservation of cell membrane integrity, anti-inflammatory, and anti-apoptotic effects. To the best of our knowledge, this study was conducted for the first time to investigate the potential beneficial effects of taurine in reducing muscle damage and inflammation in experimentally induced myositis using acetic acid. Material and Methods: The study included 24 Wistar albino rats aged 20 weeks. The rats were divided into three groups: a control group (n=8), an acetic acid (myositis) group (n=8), and a myositis + taurine 500 mg/kg/day group (n=8). Acetic acid at a concentration of 1% was used for myositis induction. Taurine treatment was administered for 15 days, after which the rats were sacrificed. The gastrocnemius muscle was evaluated histopathologically and immunohistochemically, and the results were compared statistically. Results: Significant differences were observed between the groups in terms of congestion, degeneration, necrosis, inflammation, and disorganization (p<0.01). There was also a statistically significant difference in caspase-3 levels. This difference was consistent with the histopathological findings, with p<0.01 between the acetic acid and taurine groups. Conclusion: Taurines anti-inflammatory and antioxidant properties may significantly contribute to mitigating muscle damage and inflammation. In this study, we observed a marked reduction in muscle damage and inflammation, along with the suppression of apoptosis, in rats with myositis induced by acetic acid following taurine treatment. These findings support the potential beneficial effects of taurine in reducing inflammatory muscle damage.