Rare subcutaneous metastases of papillary thyroid carcinoma revealed by 18F-FDG PET/CT
Seminars in Nuclear Medicine, cilt.56, sa.5, ss.1042-1043, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 56 Sayı: 5
- Basım Tarihi: 2026
- Doi Numarası: 10.1053/j.semnuclmed.2026.07.006
- Dergi Adı: Seminars in Nuclear Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, INSPEC, MEDLINE
- Sayfa Sayıları: ss.1042-1043
- Anahtar Kelimeler: 18F-FDG PET/CT, Papillary thyroid carcinoma, Subcutaneous metastasis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
A 76-year-old woman underwent thyroidectomy in 2010 for a 5-cm papillary thyroid carcinoma (PTC), oncocytic variant, with extrathyroidal extension, followed by 150 mCi radioactive iodine therapy (RIT). During follow-up, locoregional recurrence, pulmonary metastases, and a paraesophageal metastatic lesion developed without significant thyroglobulin elevation under TSH suppression. After additional RIT, repeat surgery, and external beam radiotherapy thyroglobulin became undetectable; however, two consecutive increases in 2026, from 1.98 to 3.57 ng/mL, prompted 18F-FDG PET/CT, which demonstrated multiple FDG-avid subcutaneous lesions (Figure 1). Punch biopsy of a shoulder lesion confirmed metastatic PTC with a focal tall-cell component and BRAF positivity (Figure 2).