Proximal Renal Tubular Acidosis and Fanconi Syndrome Associated with Tenofovir Disopyroxil Fumarat: The Importance of Arterial Blood Gas Analysis in Differrential Diagnosis of Severe Hypokalemia Tenofovir Disopiroksil Fumarata Sekonder Proksimal Renal Tübüler Asidoz ve Fanconi Sendromu: Derin Hipokalemi Ayırıcı Tanısında Arter Kan Gazı ile Değerlendirmenin Önemi

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Deniz R., Ekmen Ş. A., Ünal G. B., Hurşitoğlu M., Karaali Z.

Journal of Uludag University Medical Faculty, cilt.48, sa.2, ss.261-263, 2022 (Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.32708/uutfd.1096828
  • Dergi Adı: Journal of Uludag University Medical Faculty
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.261-263
  • Anahtar Kelimeler: Drug induced Fanconi Syndrome, Hypokalemia, Proximal renal tubular acidosis, Tenofovir Disopyroxil Fumarat
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Proximal renal tubular acidosis (pRTA) may occur alone or with Fanconi syndrome and may be idiopathic or associated with many drugs and diseases. A 71-year-old female patient was admitted with persistent, symptomatic hypokalemia, who used tenofovir disoproxil fumarate (TDF) for chronic HBV infection. While the diagnosis could not be reached by venous blood gas analysis, arterial blood gas analysis showed isolated normal anion gap hypokalemic hyperchloremic metabolic acidosis, and hypomagnesemia, hypouricemia, and hypophosphatemia were detected in biochemistry, suggesting pRTA and Fanconi syndrome. Since other etiologic causes were excluded and the history was compatible, this was attributed to the use of TDF, and clinical and laboratory response was achieved when TDF was switched into tenofovir alfenamide (TAF). TDF-associated pRTA and Fanconi syndrome may occur independently from the duration of TDF use, and switching into TAF may control this complication without disrupting the treatment of HBV infection. Confirmation with arterial blood gas might be used in the differential diagnosis of electrolyte disorders such as hypokalemia, hypomagnesemia and hypophosphatemia, mixed acid-base disorders, especially in case of unexplained etiology or inconsistency of venous blood gase analysis and clinical picture and acid-base disorders and differences in anion gap that may be missed with venous blood gas analysis alone are detected.