The assessment of protamine and perfusion related immunologic effects with complement, thromboxane and leucocyte parameters
Turk Anesteziyoloji ve Reanimasyon, cilt.20, sa.6, ss.392-397, 1992 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 20 Sayı: 6
- Basım Tarihi: 1992
- Dergi Adı: Turk Anesteziyoloji ve Reanimasyon
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.392-397
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
This study was planned in order to find out the probable immunologic reactions due to perfusion and protamine infusion and to follow up these reaction periods with specific parameters like complement (C3), (C4), (C5), thromboxane B2 (Trx B2) and leucocyte counts. Total intravenous anaesthesia was used in these 20 patients who had been scheduled for this study. Patients were premedicated with morphine 10 mg. IM and diazepam 10 mg. PO. Fentanyl+diazepam+pancuronium was used for induction. Fentanyl+pancuronium were the agents of maintenance and 4 mg/kg heparin was used and the patients were neutralized with same amount of protamine through the central venous catheter in 10 minutes time. Blood samples were taken for Trx B2, (C3), (C4), (C5), arterial blood gases and complete blood count. The samples were taken and cardiac output was measured just after the induction, before and 10 minutes after the protamine infusion. For the leucocyte count, blood samples were taken both from arterial and venous catheters. It was seen that venous leucocyte count was considerably high after protamine infusion (p < 0.01). This was positively correlated with Trx B2 values (p < 0.05). The number of platelets were also decreased after protamine infusion (p < 0.05). The increases in complements (C3), (C4), (C5) were statistically significant during by-pass. It is concluded that (C3), (C4), (C5) values are to be followed specially during bypass. As for protamine, following up the arterial-venous leucocyte counts with Trx can be a kind of immunologic reaction follow up during and after protamine infusion.