Sustained-Release Verapamil as a First-Step Drug in the Treatment of Mild to Moderate Hypertension
Journal of International Medical Research, cilt.17, sa.3, ss.268-276, 1989 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 3
- Basım Tarihi: 1989
- Doi Numarası: 10.1177/030006058901700310
- Dergi Adı: Journal of International Medical Research
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.268-276
- Anahtar Kelimeler: echocardiography, hypertension, isometric exercise, natriuresis, plasma renin activity, Sustained-release verapamil
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The efficacy of sustained-release verapamil as a first-stage treatment for mild to moderate, uncomplicated essential hypertension was studied. Nineteen patients aged 36 – 70 years (mean±SD 55±10 years) entered the study. Treatment with 240 mg sustained-release verapamil, once daily for 8 weeks, caused systolic and diastolic blood pressures to decline significantly during the first 2 weeks and this lower level was maintained until week 8. Heart rate decreased gradually during the treatment period reaching significance at week 8. After 2 weeks maximum systolic and diastolic blood pressures during isometric exercise were significantly reduced compared with pre-treatment values; there was no difference in the percentage increase occurring pre- and post-treatment. These measures for heart rate did not change significantly. Except for a significant reduction in cardiac index after 8 weeks left ventricular function and left ventricular mass were unchanged. The 24-h urinary Na+ excretion increased significantly after 2 and 8 weeks' treatment. Plasma renin activity, serum lipid concentrations and routine blood chemistries were not affected. Side-effects were transient and did not require discontinuation of therapy. In conclusion, sustained-release verapamil is an efficacious and well tolerated first-stage drug in the treatment of essential hypertension. © 1989, SAGE Publications. All rights reserved.