Helmet mask and tocilizumab for a patient with hemophagocytic lymphohistiocytosis syndrome and COVID-19: a case report
Brazilian Journal of Anesthesiology (English Edition), cilt.71, sa.1, ss.79-83, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 71 Sayı: 1
- Basım Tarihi: 2021
- Doi Numarası: 10.1016/j.bjane.2020.10.009
- Dergi Adı: Brazilian Journal of Anesthesiology (English Edition)
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Directory of Open Access Journals
- Sayfa Sayıları: ss.79-83
- Anahtar Kelimeler: COVID-19, Helmet mask, Tocilizumab, H-scores, Hemophagocytic lymphohistiocytosis (HLH)
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The management of acute hypoxemic respiratory failure and the effect of antiviral drugs in patients with severe COVID-19 have been debated. This case presents the management of a 64-year-old man COVID-19 patient admitted to the Intensive Care Unit with fever, fatigue, shortness of breath and hemophagocytic lymphohistiocytosis syndrome. Helmet mask was successfully used to treat his hypoxemic respiratory failure without any aerosol problems. Tocilizumab, an antagonist interleukin-6, was intravenously infused as an alternative drug. After administration, the high level of IL-6, CRP, ferritin, D-dimer, triglyceride, and H-scores decreased, and the patient observed good clinical and laboratory improvements. In this case report, we describe the effect of noninvasive ventilation delivered by helmet mask and antiviral drugs, and the intravenous administration of tocilizumab in a patient with hemophagocytic lymphohistiocytosis syndrome and COVID-19.