Comparison of Treatment Results and Prognostic Factors of Elderly and Young Patients Receiving Neoadjuvant Chemoradiotherapy in Rectal Cancer
UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi, cilt.32, sa.1, ss.57-64, 2022 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 1
- Basım Tarihi: 2022
- Doi Numarası: 10.4999/uhod.225730
- Dergi Adı: UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.57-64
- Anahtar Kelimeler: Aged, Radiochemotherapy, Rectal neoplasms
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In this retrospective research, it was aimed to compared elderly (≤ 65 years) and younger (< 65 years) rectal cancer patients who received neoadjuvant chemoradiotherapy (nCRT) and surgery. A total of 175 local advanced rectal cancer patients were included in this study. 60 elderly patients and 115 younger patients compared prognostic factors, treatment outcomes survival and toxicity between 2 groups of patients. At a median follow-up of 65 months in older patients and 80 months in younger patients.We found that Eastern Cooperative Oncology Groups (ECOG) performance status was significantly different between two groups (p= 0.001). None of the other treatment or patient characteristics differed significantly between the groups. The 5-year overall survival (OS) and disease-free survival (DFS) ratios were 68.0%, 44.7% for older patients and 79.0%, 50.5% for younger patients, respectively. There was no significant difference in DFS (p= 0.311) between the two age groups. However, there was significant difference in OS (p= 0.05) between the two age groups. ECOG of 0–I and ≥ 8-week interval between nCRT and surgery were significant prognostic factors for OS and DFS in the multivariate analyses for both groups Acute haematological toxicitiy, anaemia (58%) and thrombocytopenia (25%) were observed more frequently in elderly patients (p= 0.005). There were no differences in DSF between the older and younger patients, OS rates were lower in the older patient group. A higher rate of acute haematologic toxicity was observed in older patients. However, they had similar tumour responses, treatment outcomes.