Prognostic Factors Effective on Survival in Unifocal Borderline Luminal B HER2-Negative and Triple-Negative Breast Cancers: a Cross-Sectional Study
Indian Journal of Surgery, cilt.84, sa.6, ss.1231-1238, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 84 Sayı: 6
- Basım Tarihi: 2022
- Doi Numarası: 10.1007/s12262-022-03294-7
- Dergi Adı: Indian Journal of Surgery
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, Veterinary Science Database
- Sayfa Sayıları: ss.1231-1238
- Anahtar Kelimeler: Oestrogen receptor, Progesterone receptor, Breast cancer, Borderline, Prognosis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In this study, we aimed to investigate the prognostic factors and survival in unifocal borderline luminal B human epidermal growth factor 2-negative breast cancers (UBLHNBC) and unifocal triple-negative breast cancers (UTNBC). For the study, 480 consecutive patients whose postoperative treatments were completed between 1 January 2010 and 1 January 2015 were analysed. After analysis, 62 women meeting the inclusion criteria were enrolled in the study, divided into two groups as UTNBC (n:47) and UBLHNBC (n:15), and historical patient records were analysed. The UTNBC and UBLHNBC groups did not significantly differ in terms of disease-free survival (DFS) (p = 0.771) and overall survival (OS) (p = 0.973). In the multivariate analysis, pathological nodal stage was the independent risk factor for DFS [(hazard ratio (HR): 1.901) (95% CI: 1.029–3.513) (p = 0.040)], whereas perineural invasion was the only common independent risk factor for DFS [(HR: 0.143) (95% CI: 0.023–0.902) (p = 0.038)] and OS [(HR: 0.138) (95% CI: 0.027–0.703) (p = 0.017)]. Unifocal borderline luminal B human epidermal growth factor 2-negative breast cancers and unifocal triple-negative breast cancers yielded similar survival outcomes. Pathological nodal stage is the independent risk factor for disease-free survival, while perineural invasion is the independent risk factor for both disease-free survival and overall survival. For effective endocrine treatment, it is necessary to determine appropriate oestrogen receptor/progesterone receptor threshold values for both immunohistochemical subgroups.