Innovations in traumatic brain injury diagnostics: electrochemical impedance spectroscopy leading the way
Journal of Applied Electrochemistry, cilt.55, sa.1, ss.1-17, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 55 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.1007/s10800-024-02159-z
- Dergi Adı: Journal of Applied Electrochemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Compendex, INSPEC
- Sayfa Sayıları: ss.1-17
- Anahtar Kelimeler: Traumatic brain injury, Electrochemical impedance spectroscopy, Biomarker detection, Impedimetric analysis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Traumatic brain injury (TBI) poses significant challenges to the diagnosis of TBI due to its complex nature and the variability of its biomarkers. This review provides a detailed analysis of the application of electrochemical impedance spectroscopy (EIS) in the detection of mTBI biomarkers and explores its potential to address these challenges. EIS is a promising tool for improving TBI diagnostics, as it is known for its sensitivity and specificity and allows real-time monitoring of biomolecular interactions on sensor surfaces. This review highlights advances in EIS-based strategies and their contributions to improving TBI biomarker analysis, focusing on the detection of critical biomarkers, such as S100B, GFAP, UCH-L1, IL-6, and tau protein. The integration of novel electrode materials and biorecognition elements, as well as the development of portable and cost-effective biosensors, illustrate the evolving landscape of TBI diagnostics and the potential of EIS to fill existing gaps in clinical practice.