Predictive value of prognostic nutritional index on tumor stage in patients with primary bladder cancer
Archivos Espanoles de Urologia, cilt.73, sa.2, ss.132-139, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 73 Sayı: 2
- Basım Tarihi: 2020
- Dergi Adı: Archivos Espanoles de Urologia
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Gender Studies Database, MEDLINE, DIALNET
- Sayfa Sayıları: ss.132-139
- Anahtar Kelimeler: Bladder cancer, Prognostic nutritional index, Tumor stage
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
OBJECTIVES: The aim of this study was to evaluate relationship between preoperative Prognostic Nutritional Index (PNI) values and tumor stage and to identify predictive value of PNI in patients with primary bladder cancer (BC). METHODS: A total of 164 patients with primary bladder cancer were retrospectively analyzed using institutional bladder cancer database between January 2008 and January 2018. The PNI was calculated using preoperative blood sample results. According to pathological results, the patients were divided into groups as pTa (n=94), pT1 (n=54), and pT2 (n=16) and further into subgroups as Group 1 (pTa patients, n=94) and Group 2 (pT1 + pT2 patients, n=70). Subgroups were compared statistically in terms of PNI values and independent risk factors were evaluated using Backward Stepwise multivariate logistic regression analysis. ORIGINAL ARTICLE Arch. Esp. Urol. 2020; 73 (2): 132-139 RESULTS: Of patients, 145 (88.4%) were males and 19 (11.6%) were females with a mean age of 66.46±10.57 (range, 36 to 93) years. Mean total peripheral lymphocyte count was 2.11±0.71 (×109/L), mean serum albumin was 4.11±0.53 (gr/dL), and mean PNI score was 51.66±6.36. There was a statistically significant difference in serum albumin levels and PNI scores according to tumor stages (p=0.008 and p=0.003, respectively). There was a statistically significant difference in mean serum total protein, albumin, and PNI scores (p<0.01, for all). Tumor size, tumor grade, PNI, carcinoma in situ, and atypical variant status were independent risk factors for predicting tumor stage. CONCLUSIONS: Our study results demonstrate that PNI is a potential preoperative predictor of tumor stage and is an independent risk factor for predicting tumor stage in patients with primary bladder cancer. Lower PNI levels are associated with high stage disease.