THE RELATIONSHIP BETWEEN sTREM-1 AND ACTIVATION OF INFLAMMATORY BOWEL DISEASES İNFLAMATUAR BARSAK HASTALIKLARI AKTİVASYONU İLE sTREM-1 ARASINDAKİ İLİŞKİ
Istanbul Tip Fakultesi Dergisi, cilt.84, sa.3, ss.318-323, 2021 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 84 Sayı: 3
- Basım Tarihi: 2021
- Doi Numarası: 10.26650/iuitfd.2020.0090
- Dergi Adı: Istanbul Tip Fakultesi Dergisi
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.318-323
- Anahtar Kelimeler: sTREM-1, inflammatory bowel diseases, Crohn's disease, ulcerative colitis
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: In inflammatory bowel disease (IBD), there is no reliable biomarker, yet. We aimed to determine whether Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) could be useful as a marker for the diagnosis and/or the determination of disease activity in patients with IBD. Material and Method: A total of 47 patients with ulcerative colitis (UC) and 25 patients with Crohn's disease (CD) were prospectively enrolled. Clinical disease activity was analyzed using the Crohn's Disease Activity Index (CDAI) for CD and the Truelove-Witts index for UC. Results: sTREM-1 levels were significantly lower in patients with IBD compared to healthy controls (p=0.001). In comparison of the levels of sTREM-1 between the different groups (CD, UC, and healthy controls) the difference was statistically significant. No considerable differences in sTREM-1 levels were determined in patients with active versus quiescent disease. The sTREM-1 levels negatively correlated with C-reactive protein, blood neutrophil-lymphocyte ratio, and positively with haemoglobin levels. Conclusion: sTREM-1 levels are decreased in IBD patients compared with the healthy individuals. It may, therefore, be useful for the diagnosis of IBD. However, it does not seem to be a precise marker of disease activity in IBD and cannot be suggested for assessing disease activity in these patients.