Evaluation of the Relationship Between Trace Elements and Chronic Constipation in Children-Case Control Study Çocuklarda Eser Elementler ve Kronik Kabızlık Arasındaki İlişkinin Değerlendirilmesi-Vaka Kontrol Çalışması
Turkiye Klinikleri Pediatri, cilt.32, sa.3, ss.122-128, 2023 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 3
- Basım Tarihi: 2023
- Doi Numarası: 10.5336/pediatr.2023-97670
- Dergi Adı: Turkiye Klinikleri Pediatri
- Derginin Tarandığı İndeksler: Scopus, Academic Search Premier, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.122-128
- Anahtar Kelimeler: child, Chronic constipation, trace element
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Chronic constipation is one of the most common diseases in childhood and 95% of constipation cases in children are functional. It has been shown that disruption in the intestinal ecosystem is closely related to constipation. Copper (Cu), zinc (Zn), chromium (Cr) and selenium (Se) are important trace elements, they play an important role in the normal functioning of all systems in the body and are very important for the intestinal ecosystem. The aim of this study is to investigate the role of trace elements in chronic constipation in children. Material and Methods: This study was carried out in pediatric patients diagnosed with chronic constipation according to Rome IV criteria in the pediatric gastroenterology outpatient clinic between January and October 2020. Serum copper, zinc, chromium and selenium concentrations of patients with chronic constipation were measured. Results: The study group consisted of 61 children with chronic constipation (59% girls, 41% boys; age: 6.9±4.7 years); the control group consisted of 30 healthy children (60% girls, 40% boys; age: 7.0±3.3 years). There was not any significant differences between the groups according to trace element levels (for all analysis, p>0.05). A weak, negative correlation was found between Cu levels and age (r=-0.266, p=0.038). A weak, positive correlation was found between Se and duration of constipation (r=0.324, p=0.011). No significant differences were found between trace element levels by gender (for all analyses, p>0.05). Malnutrition (mild) was detected in 23% of the patients and 26.7% of the control group (p=0.34). In patients with malnutrition in the patient group, Se level was found to be significantly higher than those with normal weight (p=0.037). There was a weak negative correlation between Zn and weight and height z scores in the patient group (r=-0.260, p=0.043, r=-0.317, p=0.013). Conclusion: Trace elements, especially Selenium, may be associated with chronic constipation and duration of constipation in children. More comprehensive prospective studies are needed to understand the relationship between trace elements and constipation in children.