Resistance status of antibiotics in Gram-positive bacteria isolated from acne lesions in Istanbul
Turkderm Deri Hastaliklari ve Frengi Arsivi, cilt.51, sa.2, ss.32-36, 2017 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 2
- Basım Tarihi: 2017
- Doi Numarası: 10.4274/turkderm.23169
- Dergi Adı: Turkderm Deri Hastaliklari ve Frengi Arsivi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.32-36
- Anahtar Kelimeler: Antibiotic resistance, topical, acne, Istanbul
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background and Design: Acne vulgaris is a multifactorial disease in which Propionibacterium acnes is thought to play an important role in the pathogenesis of inflamed lesions. There is also significant in vitro evidence suggesting a possible pathogenetic role for Staphylococci in acne vulgaris and an in vitro study of patients who were undergoing evaluation for acne, showed that 53% of participants were colonised with Staphylococcus epidermidis. Materials and Methods: In this study, 29 P. acnes isolates and 61 coagulase-negative staphylococci (CNS) isolates were obtained from 169 specimens belonging to patients with inflammatory acne vulgaris and the antimicrobial susceptibilities of these isolates against nadifloxacin, erythromycin, clindamycin and tetracycline were determined at the minimum inhibitory concentration levels, using the 'Clinical and Laboratory Standards Institute' agar dilution method. Results: There were no P. acnes isolate resistant to the antibiotics tested in this study and the antibiotic resistance status among CNS was as 28%, 36%, 23% and 0% for tetracycline, erythromycin, clindamycine and nadifloxacin, respectively. Conclusion: According to the results of this study, it may be expected that nadifloxacin could be more effective in the treatment of acne than other antimicrobial agents because of having no resistance to both P. acnes and CNS. However, this must be supported by clinical trials. Although resistance rates were found to be relatively low in this study, the antibiotic resistance problem should be taken into consideration while planning a treatment to get successful results. In case of treatment failures, presence of drug resistant strains should be considered.