Treatment and outcome of idiopathic focal segmental glomerulosclerosis: Immunosuppressive agents or renin angiotensin system inhibitors İdiopatik fokal segmental glomerüloskleroz olgularinda tedavi ve sonuçlar: Baǧişikliǧi baskilayici ajanlar ya da renin anjiyotensin sistem i̇nhibitörleri
Turkish Nephrology, Dialysis and Transplantation Journal, cilt.20, sa.3, ss.277-283, 2011 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 20 Sayı: 3
- Basım Tarihi: 2011
- Doi Numarası: 10.5262/tndt.2011.1003.12
- Dergi Adı: Turkish Nephrology, Dialysis and Transplantation Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.277-283
- Anahtar Kelimeler: Focal segmental glomerulosclerosis, Immunosuppression, Nephrotic syndrome, Proteinuria, Renin-angiotensin system
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
OBJECTIVE: We compared the efficacy and safety of 12 months of three different treatment regimens. MATERIAL and METHODS: We retrospectively investigated the pathological and clinical features of 70 patients with FSGS confirmed by biopsy. Patients with secondary FSGS, estimated glomerular filtration rate <30 mL/min/1.73 m2 and history of diabetes mellitus were excluded. Eligible 51 patients were randomly assigned to receive treatment with renin-angiotensin system (RAS) inhibitors (group 1, n=13), steroid (group 2, n=22) or steroid + Cyclosporine (CsA) (group 3, n=16). RESULTS: At the end of the one year, remission ocurred in 7 patients (53.8%) (4 complete and 3 partial) in group 1, 15 patients (68%) (12 complete and 3 partial) in group 2 and 8 patients (50%) (6 complete and 2 partial) in group 3 (p=0.483). The baseline proteinuria levels of patients in group 2 (5.41±3.91 g/day) and group 3 (5.96±4.83 g/day) were significantly decreased to 2.03±3.16 g/day (p=0.004) and 2.03±2.40 g/day (p=0.012), respectively. However, the baseline proteinuria levels of patients in group 1 were not significantly decreased at one year of treatment. CONCLUSION: Steroid treatment or CsA in combination with low-dose steroids show similar efficacy in inducing remission in patients with idiopathic FSGS.