Effects of 5-fluorouracil released from different prosthetic meshes on post-operative adhesion formation in rats İntraabdominal Yerleştirilen Sentetik Greft Materyallerinden Salınan 5- Flourourasil’in İntraabdominal Adezyon Gelişimi Üzerine Etkisi
Northern Clinics of Istanbul, cilt.9, sa.6, ss.565-575, 2022 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 6
- Basım Tarihi: 2022
- Doi Numarası: 10.14744/nci.2021.45548
- Dergi Adı: Northern Clinics of Istanbul
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Central & Eastern European Academic Source (CEEAS), Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.565-575
- Anahtar Kelimeler: Adhesions, polyglactin 910-chitosan gel, polypropylene, 5-fluorouracil
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
OBJECTIVE: Post-operative adhesion is a common problem in abdominal surgery. Especially, foreign materials are strong stimulus for the development of adhesions. The aim of this study was to investigate whether drug release material coated prosthetic mesh decreases intra-abdominal adhesion formation or not. METHODS: 5-Fluorouracil (5-FU) releasing “chitosan gels” were loaded to polypropylene and polyglactin-910 grafts. Poly-propylene, polyglactin-910 grafts, chitosan gel, and 5-FU-loaded polyglactin 910, polypropylene grafts were used to cover abdominal defects of rats which were created under sterile conditions (n=84). Each group was divided into two subgroups (n=6). Subgroups were sacrificed on the 7th and 30th days. RESULTS: The 7th day macroscopic examinations were similar. Polypropylene group was most adhesive group on the 30th day. There were less adhesions in chitosan gel and 5-FU-loaded groups. Capsule and capsule margins showed no difference on both the 7th and 30th days. Polypropylene-5-FU group and polypropylene-chitosan gel group showed significantly less macroscopic adhesions than polypropylene control group. Furthermore, polyglactin-910-chitosan gel group was less adhesive than polypropylene control group. CONCLUSION: This study showed that 5-FU decreases the adhesions but the dosage and release kinetics need further investigations.