Analysis of Patients Undergoing Metronidazole Challenge Testing: Real-Life Data

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Telli O., AKSU K., Akkale O., Celik Tuglu H., Yagdiran M., Dindar Celik F., ...Daha Fazla

Asthma Allergy Immunology, cilt.23, sa.1, ss.64-69, 2025 (ESCI, Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 1
  • Basım Tarihi: 2025
  • Doi Numarası: 10.21911/aai.2025.736
  • Dergi Adı: Asthma Allergy Immunology
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.64-69
  • Anahtar Kelimeler: Metronidazole, drug hypersensitivity reaction, drug provocation test, beta-lactam antibiotic hypersensitivity
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Objective: We aimed to investigate hypersensitivity reactions in patients who underwent the metronidazole oral provocation test in the tertiary immunology and allergy clinic. Materials and Methods: This retrospective study included patients who had a history of antibiotic hypersensitivity reactions to antibiotics other than metronidazole and underwent the metronidazole oral provocation test at an immunology and allergy clinic in a tertiary hospital between January 1, 2017 and December 31, 2023. Hypersensitivity reactions that developed during the metronidazole oral provocation test were recorded. Results: A total of 82 patients were included in the study with 63 (76.83%) being female. The mean age of the patients was 50.14±12.47 years. A history of antibiotic hypersensitivity reactions to beta-lactams was present in 59 (71.95%) patients. During the metronidazole oral provocation test, immediate hypersensitivity reactions developed in 2 (2.43%) patients and delayed hypersensitivity reaction developed in 1 (1.21%) patient. Conclusion: The rate of metronidazole drug hypersensitivity confirmed by the drug provocation test was found to be 3.65% in subjects with a history of hypersensitivity reactions to antibiotics other than metronidazole. Patients with a history of hypersensitivity reactions to antibiotics other than metronidazole generally tolerated metronidazole well.